Microbiome plays an important role in the pathogenesis of IBD. Several pioneering studies supporting the importance of the intestinal microbiota were performed by our research group. We helped to describe the intestinal dysbiosis in both CD and UC. More recently, we described a microbial signature able to predict pouchitis following colectomy and IPAA in UC.
Presently, we are using DNA sequencing technology in new studies over the microbiome. These techniques allow us to gather much more information about bacteria, viruses and fungi. We want to apply these techniques in both fecal samples as in tissue and saliva samples. We also want to study the modulation of the intestinal microbiome through diet and fecal microbiota transplantation.
VIB Grand Challenges funding - Microbiota modulation strategies in Inflammatory Bowel Disease management - MIMOSA project: